The potential of repurposing cipargamin for treating Babesia species offers both theoretical advancements and practical applications in combating parasitic infections.

This study provides important findings on the neural circuits underlying dishabituation of the olfactory avoidance response in Drosophila. The data as presented provide solid evidence that the ...

Trained immunity is a form of innate immune cell memory that is being developed as a novel immunotherapeutic approach for cancer treatment.

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells.

This valuable study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in increased ...

During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

A novel virtual reality-based contextual fear conditioning paradigm for head-fixed mice that elicits robust freezing behavior and enables multiphoton imaging of neural circuits underlying learning, ...

The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.

A new state-of-the-art diagnostic test for animal African trypanosomiasis could detect sentinels of infection in domestic animals and aid control efforts.

Fingertip tactile neurons collectively encode the skin's viscoelastic state alongside current touch, potentially enabling the brain to better interpret forces during manipulation.

This important study demonstrates the significance of incorporating biological constraints in training neural networks to develop models that make accurate predictions under novel conditions. By ...