The conservative Supreme Court dealt a significant blow to transgender Americans on Wednesday, issuing a sweeping decision that may have implications beyond the medical care that was at center of one of the court’s highest-profile disputes this year.

Advocates said the high court's decision to uphold state bans on gender-affirming care is a major blow to transgender rights.

The U.S. Supreme Court said Tennessee did not violate the constitution by banning gender-affirming care for transgender minors. The case is sure to resonate nationally.